Medical Therapeutics

Amber Bio

Brief Description

A biotechnology company offering genetic medicine through biologically inspired design. The company offers gene editing modalities using multi-kilobase RNA writing to easily reach previously undruggable diseases, enabling medical researchers to easily develop independent therapies for each separate mutation in the patient population.

Timeline 2021. Company founded Inventor

Jennifer Doudna

Inapill

Brief Description

Inapill is developing novel therapeutics that tune immune cell metabolism (immunometabolism) to treat diseases caused by immune system overactivation and excessive inflammation.

Timeline 2023. Company founded; tenant at Bakar Labs, in the UC Berkeley Bakar BioEnginuity Hub Inventors

Kaoru Saijo, Greg Timblin

Lyterian Therapeutics, Inc.

Brief Description

Lyterian Therapeutics is committed to developing transformative medicines for patients by co-opting physiologically relevant protein homeostatic mechanisms to regulate genetically-validated targets. Lyterian is derived from λυτήριος or lutḗrios, which means termination, healing, or end of disease. Disease resolution is coordinated by endogenous and exogenous agents that recruit cells and other effectors to the site of injury. Lyterian Therapeutics medicines are inspired by the logic that orchestrates homeostatic equilibria and drives healing.

Timeline 2022....

Mimesyn

Brief Description

Developing a novel class of molecules, aza-@-tides, that mimic the structural features of natural amino acids. These can be synthesized from amino acid precursors in either direction using standard peptide synthesis methods, facilitating the assembly of libraries incorporating all the amino acid building blocks.

Timeline 2004. Company founded Inventors

Paul Bartlett, Ming Chen Hammond, Stephen Olson, Scott Phillips, Miroslav Rezac

Vicinitas Therapeutics

Brief Description

Vicinitas Therapeutics is a biotechnology company focused on targeted protein stabilizers known as Deubiquituinase Targeting Chimeras (DUBTACs). The company’s mission is to use this proprietary technology to solve critical problems in human health by developing next-generation disease therapies against an entire class of previously inaccessible disease-causing proteins. The company spun out of technology that was developed through an academic-industry collaboration between UC Berkeley researchers and Novartis Institutes for BioMedical Research.

Timeline 2022...

ReRx Therapeutics

Brief Description

ReRx is developing novel oral therapeutics to treat patients with severe metabolic diseases including obesity, metabolic syndrome, diabetes, and liver diseases. The company's therapeutics target metabolic pathways involved in regulating energy homeostasis and improve treatment outcomes compared to similar pharmacological agents.

Timeline 2023. Company founded Inventors

Chi Zhu, Anders Michael Naar, Justin Yu-Sun Lee

GenoptX, LLC

Brief Description

A CRISPR-based gene editing company.

Formerly known as Syncodi.

Timeline 2019. Company founded. Inventors

Jennifer Doudna, Abraham Isser Flamholz, Dana Nadler, Benjamin Oakes, David Frank Savage

Geneditor Biosciences, Inc.

Brief Description

Geneditor Biosciences is a pre-clinical stage gene editing company focused on the treatment of rare cancers with unmet medical needs.

Timeline 2021. Company founded. Inventor

Jennifer Doudna

Evercrisp Biosciences

Brief Description

Evercrisp Biosciences is a biotechnology company engineering self-deliverable CRISPR genome editors intended to improve the area of oncology. The company focuses on the discovery and development of protein-based genome editors as therapeutics for multiple disease areas, enabling healthcare organizations to have novel enzymes with high cell permeability and editing efficiency.

Timeline 2021. Company founded. Inventor

Jennifer Doudna

DNA Nanobots, LLC

Brief Description

With a portfolio of existing IP, DNA Nanobots develops products for targeted therapeutics and functionalized gene delivery. We have a dual approach, building partnerships to provide development expertise in the functionalization of DNA nanotechnology with experience in Gene Delivery, Vaccine Development, Targeted Drug Delivery, Biosensing, Immunotherapy, and Drug Discovery.

Timeline 2021. Company founded. Inventors

Jennifer Doudna, Enrique Lin Shiao, Rachael Lew