Medical Therapeutics

HypO2Regen’s is developing novel, disease-modifying therapeutics for chronic intractable inflammatory diseases, including what would be the first cell-free stem cell treatment that induces true regeneration of tissue damaged by chronic inflammation. The company's first focus on improving the lives of more than 300 million people in the United States and Europe with moderate to severe periodontitis, up to 70% of whom are either undertreated or untreated.

Phillip Messersmith, Jing Cheng, Ellen Heber-Katz

With synthetic DNA fueling innovation in biological research, therapeutics, diagnostics, and biomanufacturing, there is an urgent need for faster and more accurate DNA synthesis. Currently, DNA is manufactured via a chemical method that has remained essentially unchanged for 35 years and has approached a plateau. Ansa Biotechnologies is developing a faster, more accurate, and cleaner enzyme-based DNA synthesis technology. The technique promises to dramatically accelerate innovation in biological research and engineering.

The approach is based on polymerase-...

Pow.Bio provides intelligent fermentation services for industrial and synthetic biology. The company has built an AI platform that rapidly identified better-performing process conditions, increasing output 2–3x from existing infrastructure within just 100 days. The company's services combine continuous fermentation with advanced control methodology to quickly optimize the fermentation process and deliver high yields at low cost. The scale runs from 1-100 liter capacity for bacteria, yeast, and filamentous fungi. The first-of-its-kind fermentation technology solves the...

Evergreen Saponins is commercializing a sustainable, scalable production method for saponins, unlocking a new supply chain for an essential ingredient in processed food, bio-pesticides, medicines, vaccines, and more. Early in his career, company founder Dr. Ricardo San Martin developed techniques for harvesting saponins from the wood and bark of mature wild trees in Chile, fueling demand for the additive worldwide. Now the chemical engineer has invented a breakthrough method to extract commercial-grade saponins from the leaves of Chilean soapbark trees, Quillaja...