Medical Therapeutics

Ansa Biotechnologies

Brief Description

With synthetic DNA fueling innovation in biological research, therapeutics, diagnostics, and biomanufacturing, there is an urgent need for faster and more accurate DNA synthesis. Currently, DNA is manufactured via a chemical method that has remained essentially unchanged for 35 years and has approached a plateau. Ansa Biotechnologies is developing a faster, more accurate, and cleaner enzyme-based DNA synthesis technology. The technique promises to dramatically accelerate innovation in biological research and engineering.

The approach is based on polymerase-...

Stylus Medicine

Brief Description

Stylus Medicine has created a new gene editing technology based on viral proteins called recombinases. These proteins naturally insert large swaths of DNA into bacterial genomes, but Stylus used machine learning to design recombinases that target specific regions of the human genome. The method is based on the pioneering work of Patrick Hsu, UC Berkeley assistant professor of bioengineering and co-founder and a core investigator of the Arc Institute. The company is on a mission to develop next-generation therapies for disease through genome engineering and chromatin...

Pow.Bio

Brief Description

Pow.Bio provides intelligent fermentation services for industrial and synthetic biology. The company has built an AI platform that rapidly identified better-performing process conditions, increasing output 2–3x from existing infrastructure within just 100 days. The company's services combine continuous fermentation with advanced control methodology to quickly optimize the fermentation process and deliver high yields at low cost. The scale runs from 1-100 liter capacity for bacteria, yeast, and filamentous fungi. The first-of-its-kind fermentation technology solves the...

Tenaya Therapeutics

Brief Description

Tenaya Therapeutics is shaping the future of heart disease treatment driven by a mission to discover, develop, and deliver curative therapies that address the underlying drivers of heart disease. Tenaya is developing therapies for rare genetic disorders as well as for more prevalent heart conditions through three platforms: Gene Therapy, Cellular Regeneration, and Precision Medicine. The company was spun out of a new method for creating three-dimensional human heart tissue from stem cells, developed in a collaboration between UC Berkeley Professor of Materials Science...

Evergreen Saponins

Brief Description

Evergreen Saponins is commercializing a sustainable, scalable production method for saponins, unlocking a new supply chain for an essential ingredient in processed food, bio-pesticides, medicines, vaccines, and more. Early in his career, company founder Dr. Ricardo San Martin developed techniques for harvesting saponins from the wood and bark of mature wild trees in Chile, fueling demand for the additive worldwide. Now the chemical engineer has invented a breakthrough method to extract commercial-grade saponins from the leaves of Chilean soapbark trees, Quillaja...

Sift Biosciences

Brief Description

Sift Biosciences supercharges existing cancer therapies by leveraging artificial intelligence and high-throughput cellular screening to discover and design immunotherapy boosters that significantly extend cancer patient survival. The company was co-founded by Yue Clare Lou (BS ’18 Microbial Biology; PhD ’23 Microbiology) and Maddie Williams (PhD student '23-present, Molecular & Cell Biology) to commercize technology developed during their doctoral research at UC Berkeley.

Timeline 2024. Company founded Inventors

Yue "Clare" Lou, Madeline Dee...

CryoVox Technologies

Brief Description

Crovox Technologies is developing new tools for the mass manufacturing of 3D cell cultures.

Timeline 2024. Company founded Inventors

Boris Rubinsky, Michal Adamkievicz, Ze'ev Shaked

KaRNAteq, Inc.

Brief Description

KaRNATeq develops tools for RNA sequencing that are the next step forward in genomics. The enzymes developed by the company enable doctors and scientists to capture more information at reduced cost.

Timeline 2019. Company founded Inventors

Kathleen Collins, Heather Upton

Addition Therapeutics

Brief Description

Addition is transforming genetic medicine by developing RNA-only therapeutics that PRINT™ any genetic element at specific safe harbor sites.

Timeline 2021. Company founded Inventors

Kathy Collins, Jeremy John McIntyre, Sarah Madeline Palm, Heather Upton, Briana Nicole Van Treeck. Xiaozhu Zhang

Juvena Therapeutics

Brief Description

Juvena Therapeutics is a venture-backed biopharma startup discovering novel protein-based therapeutics that promote tissue regeneration in the elderly and treat various age-related diseases. We are building a protein-based discovery platform by implementing an efficient identification, screening and preclinical development pipeline.

Timeline 2017. Company founded Inventors

Michael Conboy, Irina Conboy, David Schaffer, and Hanadie Yousef