Medical Therapeutics

ReRx Therapeutics

Brief Description

ReRx is developing novel oral small molecule therapeutics to treat patients with severe metabolic diseases including obesity, metabolic syndrome, diabetes, and liver diseases. The company's therapeutics target metabolic pathways involved in regulating energy homeostasis and improve treatment outcomes compared to similar pharmacological agents.

Obesity and its associated metabolic diseases remain leading causes of preventable illness and mortality worldwide. Current front-line treatments, notably injectable incretin analogs that suppress appetite and reduce food...

Sift Biosciences

Brief Description

Sift Biosciences supercharges existing cancer therapies by leveraging artificial intelligence and high-throughput cellular screening to discover and design immunotherapy boosters that significantly extend cancer patient survival. The company was co-founded by Yue Clare Lou (BS ’18 Microbial Biology; PhD ’23 Microbiology) and Maddie Williams (PhD student '23-present, Molecular & Cell Biology) to commercize technology developed during their doctoral research at UC Berkeley.

Inventors

Yue "Clare" Lou, Madeline Dee Williams

Company Founders

Yue "Clare" Lou (...

Tessera Therapeutics, Inc.

Brief Description

Developer of gene writing technology designed to permanently make small and large alterations to the human genome. The company's technology helps scientists and clinicians with the ability to write small and large therapeutic messages into the genome to treat diseases at their source, enabling healthcare providers to cure their patients and improve their lives.

Tessera Scientific Advisory Board Member David Schaffer co-invented the company's foundational technology as UC Berkeley Professor of Chemical and Biomolecular Engineering, Bioengineering, Molecular and Cell...

Scribe Therapeutics

Brief Description

Scribe is focused on the engineering, delivery, and development of next-generation CRISPR molecules to rewrite and repair the underlying cause of genetic disorders. The molecular engineering company was spun out of discoveries in the lab of UC Berkeley Professor of Biochemistry, Biophysics and Structural Biology and Nobel Laureate Jennifer Doudna. Doudna co-founded Scribe with company CEO Benjamin Oakes, who received a PhD in Molecular and Cellular Biology from UC Berkeley in 2017, where he worked in the Doudna Lab and Savage Lab, UC Berkeley Associate Professor of...

GenoptX, LLC

Brief Description

A CRISPR-based gene editing company.

Formerly known as Syncodi.

Inventors

Jennifer Doudna, Abraham Isser Flamholz, Dana Nadler, Benjamin Oakes, David Frank Savage

Timeline 2019. Company founded.

Genocea Biosciences, Inc.

Brief Description

Genocea finds targets of T cell responses to discover and develop life-changing medicines. The company created a pipeline of novel vaccine and immunotherapy programs that stimulate the T cell arm of the immune system, which is increasingly recognized as critical to generating protective immune responses against a wide array of diseases. Genocea designs its medicines using ATLASª, a proprietary technology platform. Genocea's platform has the potential to revolutionize vaccines and immunotherapies for a range of infectious diseases, cancers and autoimmune diseases. The...

Geneditor Biosciences, Inc.

Brief Description

Geneditor Biosciences is a pre-clinical stage gene editing company focused on the treatment of rare cancers with unmet medical needs.

Inventors

Jennifer Doudna

Company Founders

Jennifer Doudna

Timeline 2021. Company founded.

GenEdit, Inc.

Brief Description

GenEdit develops innovative therapies through targeted delivery of genetic medicines. The GenEdit founders share the vision that recent scientific advancements in engineering CRISPR components and delivery vehicles offer a groundbreaking opportunity to develop safe and effective medicines for genetic diseases.

The company's proprietary Polymer nanoparticle can deliver CRISPR protein and gRNA. CRISPR in a protein form has many advantages, delivery has been a challenge limiting its application. To deliver CRISPR protein, encapsulation of CRISPR ribonucleoprotein (RNP...

Frontier Medicines Corporation

Brief Description

Frontier Medicines was founded to develop medical treatments for currently "undruggable" diseases. The clinical stage precision medicine company pioneers medicines for genetically-defined patient populations in oncology and immunology, and plans to broaden its therapeutic focus over time. The company uses chemoproteomics - an innovative approach to chemically interrogate proteins in living systems – to discover and pharmacologically target new binding pockets (or "hotspots") on proteins, making them accessible to small-molecule drug discovery and development. The...

Excellin Life Sciences, Inc.

Brief Description

Bionic chip technology that merges a living biological cell with electronic circuitry. This chip-based instrument allows for verification of transfection, enabling downstream assays and in situ detection of results, for use in basic research on cell death and drug toxicity.

Formerly known as Bioelectronic Micro Systems, Inc.

Inventors

Yong Huang, Boris Rubinsky

Timeline 2000. Company founded.